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Senior Software / AI Engineer

Pathos AI

2 days ago
LLM EngineeringOnsiteSeniorvia Hacker News

About the Role

Pathos AI | Senior Software / AI Engineer | NYC (hybrid, 3-4 days onsite) | Full-time | $180-200K + equity | VISA

Pathos is an oncology biotech building AI as the operating system for drug development. We have:

  • 200+ petabytes of multimodal patient data linked to outcomes
  • The largest foundation model in oncology (in development)
  • Backing to build a generational company
  • Founded by Eric Lefkofsky (Tempus) and Ryan Fukushima

Learn more: pathos.com

This role is 0→1 product work. You'll build:

  • AI agents and copilots for internal teams (BD, clinical, computational biology, lab)
  • MCP-style servers so agents can safely interact with internal systems
  • Data pipelines into a governed warehouse / knowledge graph

Looking for senior software/ML engineers who:

  • Have 4+ years shipping user-facing systems
  • Are fluent in Python + TypeScript/JavaScript, comfortable full-stack
  • Have built LLM-powered workflows (OpenAI API or similar)
  • Have production experience with APIs, eventing, data engineering (GCP/BigQuery a plus)
  • Bonus: prior agent/retrieval/ML infra work, or experience in regulated clinical environments

Hybrid in NYC (3-4 days onsite). $180-200K base + equity (3-yr vest, no liquidity until exit). Visa support available.

Apply: email chris.poshka+hn@pathos.com.

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